Microwave assisted synthesis of novel imidazo [2,1-b]thiazole derivative attached to quinoxalinones

3-(6-Phenylimidazo[2,1-b]thiazol-5-yl)quinoxalin-2(1H)-ones (qunoxalinone) (6a–q) have been synthesized by the reaction of ethyl 2-oxo-2-(6-phenylimidazo[2,1-b]thiazol-5-yl)acetates (4a–e) with suitably substituted o-phenylenediamines (5a–f) under microwave heating. The ethyl 2-oxo-2-(6-phenylimidazo[2,1-b]thiazol-5-yl)acetates (4a–e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (3a–e) with ethyl chlorooxoacetate in refluxing 1,4-dioxane whereas the thiazoles (3a–e) were synthesized by the reaction of 2-bromo-1-phenylethanones (2a–e) with thiazol-2-amine in refluxing acetone.