Title of article :
Facile, diversity-orientated one-pot synthesis of ethyl 1,5-disubstituted-1H-1,2,4-triazole-3-carboxylates
Author/Authors :
Degorce، نويسنده , , Sébastien and Delouvrié، نويسنده , , Bénédicte and Davey، نويسنده , , Paul R.J. and Didelot، نويسنده , , Myriam and Germain، نويسنده , , Hervé and Harris، نويسنده , , Craig S. and Brempt، نويسنده , , Christine Lambert-van der and Lebraud، نويسنده , , Honorine and Ouvry، نويسنده , , Gilles، نويسنده ,
Abstract :
Access to the 1,5-disubstituted-1H-1,2,4-triazole-3-carboxamide motif is quite laborious and requires forcing conditions to effect the cyclocondensation step. Herein, we report an efficient and mild one-pot protocol to access this substructure in good chemical yields with high regiocontrol.
Keywords :
Ethyl 1 , 5-disubstituted-1H-1 , 2 , cyclodehydration , 4-triazole carboxylates , Regioselective acylation of N-substituted hydrazines
