Author/Authors :
Baciu-Atudosie، نويسنده , , Lavinia and Ghinet، نويسنده , , Alina and Belei، نويسنده , , Dalila and Gautret، نويسنده , , Philippe and Rigo، نويسنده , , Benoît and Bîcu، نويسنده , , Elena، نويسنده ,
Abstract :
A simple one-pot approach for the synthesis of new pyrazolones containing a phenothiazine unit is reported. Compound 4b was evaluated for its antiproliferative activity on a NCI-60 cancer cell line panel and exhibited selective cytostatic activity toward CCRF–CEM, HL-60(TB), K-562, MOLT-4, and RPMI-8226 leukemia cell lines.
Keywords :
Pyrazolone , Phenothiazine , one-pot reaction , hydrazine
