Title of article
Rapid and clean microwave-assisted synthesis of N-acetylneuraminic acid methyl ester and its β-methyl glycoside
Author/Authors
Chopra، نويسنده , , Pradeep and Thomson، نويسنده , , Robin J. and Grice، نويسنده , , I. Darren and von Itzstein، نويسنده , , Mark، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
6254
To page
6256
Abstract
The effect of microwave irradiation on the synthesis of N-acetylneuraminic acid methyl ester and its β-methyl glycoside is investigated. On a 1 g scale, a high yield (94%) of the methyl ester was obtained after 15 min at 80 °C. Acceleration of the glycosidation reaction was achieved, with the β-methyl glycoside isolated in good yield following optimisation of reaction conditions to 15 min at 120 °C.
Keywords
Sialic acid , microwave , N-Acetylneuraminic acid methyl ester , ?-Methyl glycoside
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882670
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