Synthesis of isomeric corniculatolides

Synthesis of three natural macrolides 11-O-methylcorniculatolide A, 11-O-methylisocorniculatolide A and isocorniculatolide A is reported using a simple, straight forward and high-yielding route. The present synthesis confirms the assigned molecular structures and provides an access to sufficient quantities of the natural products for the biological evaluation. In addition, we have determined the anti-TB potential of the three natural compounds using Alamar-Blue assay (H37Rv) and found no significant inhibitory activity at 100 μg/ml. Excellent yields, short sequence and useful SAR information are the highlights of the present work.