Author/Authors :
Palazzolo، نويسنده , , Martيn A. and Pérez-Sلnchez، نويسنده , , Marيa and Iribarren، نويسنده , , Adolfo M. and Lewkowicz، نويسنده , , Elizabeth S. and Domيnguez de Marيa، نويسنده , , Pablo، نويسنده ,
Abstract :
Organocatalysis is assessed for the first time in the synthesis of purine and pyrimidine acyclic nucleosides providing high yields and straightforward work-up procedures. Nucleobases containing aldehydes are catalytically ligated (C–C bond formation) to acetone or to phosphonate-containing ketones by means of pyrrolidine or silica-immobilized piperazine as amine-based organocatalysts.
Keywords :
Piperazine , acyclic nucleosides , organocatalysis , pyrrolidine , Phosphonate
