A facile sequential three-component regio- and stereoselective synthesis of novel spiro-isoxazoline/acridinone hybrids

A series of novel spiro-isoxazoline/acridinone hybrids has been synthesized regio- and stereoselectively via three-component sequential reactions of 3,4-dihydroacridin-1(2H)-one, aromatic aldehydes and benzohydroximinoyl chlorides in the presence of potassium hydroxide at ambient temperature in good yields. This one pot three-component sequential transformation proceeds via Knoevenagel condensation/1,3-dipole generation/1,3-dipolar cycloaddition sequence.