Title of article
Asymmetric addition of benzothiazole to N-tert-butanesulfinyl imine for the synthesis of chiral α-branched heteroaryl amines
Author/Authors
Zhang، نويسنده , , Jinlong and Yang، نويسنده , , Yuhong and Wang، نويسنده , , Mei and Lin، نويسنده , , Li and Wang، نويسنده , , Rui، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
6893
To page
6896
Abstract
This work concerns the asymmetric additions of benzothiazole to a variety of N-tert-butanesulfinyl imines with excellent diastereoselectivities (d.r. up to >99:1). Amino alkoxyl lithium was the key additive to obtain the excellent diastereoselectivity. More functionalized 4-methyl-5-vinyl thiazole and alkyl imines which can isomerize to enamines are also compatible substrates to the present protocol.
Keywords
Diarylmethylamine , N-tert-Butanesulfinyl imine , diastereoselectivity , asymmetric synthesis , benzothiazole
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1883019
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