Title of article
Tandem hydroboration/reduction of trisubstituted β,γ-unsaturated esters for the asymmetric synthesis of chiral 1,3-diols
Author/Authors
Fordred، نويسنده , , Paul S. and Bull، نويسنده , , Steven D.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
27
To page
31
Abstract
Treatment of a range of trisubstituted β,γ-unsaturated esters with 2 equiv of (−)-monoisopinocampheylborane results in hydroboration of their alkene functionalities and reduction of their ester groups to afford chiral 1,3-diols containing two new vicinal β,γ-(anti)-stereocentres in 67–85% enantiomeric excess.
Keywords
Hydroboration , ? , ?-Unsaturated ester , Chiral 1 , 3-diol , IpcBH2 , Reduction
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883225
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