Title of article
Synthesis of azafluorenone via oxidative intramolecular Heck cyclization
Author/Authors
Dhara، نويسنده , , Shubhendu and Ahmed، نويسنده , , Atiur and Nandi، نويسنده , , Sukla and Baitalik، نويسنده , , Shantanu and Ray، نويسنده , , Jayanta K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
63
To page
65
Abstract
A very short and highly efficient protocol to azafluorenone exploiting intramolecular oxidative Heck cyclization using Pd(0) is presented. Precursor alcohols afforded azafluorenone in a single step with simultaneous oxidation and cyclization under Heck reaction condition in excellent yield. This methodology could be very much crucial in the total synthesis of azafluorenone alkaloids for promising pharmacological activity.
Keywords
Azafluorenone , 2-Bromoprydine-3-carboxaldehyde , Intramolecular Heck reaction , Grignard reaction
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883245
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