Title of article
Tandem approach for the synthesis of imidazo[1,2-a]pyridines from alcohols
Author/Authors
Ramesha، نويسنده , , Ajjahalli B. and Raghavendra، نويسنده , , Goravanahalli M. and Nandeesh، نويسنده , , Kebbahalli N. and Rangappa، نويسنده , , Kanchugarakoppal S. and Mantelingu، نويسنده , , Kempegowda، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
95
To page
100
Abstract
Propylphosphonic anhydride (®T3P) is shown to be an effective and mild reagent for the one-pot synthesis of imidazo[1,2-a]pyridines from a variety of alcohols. Alcohols are oxidized in situ to aldehydes under mild conditions, which in turn undergo a three-component reaction with various 2-aminopyridines and isocyanides to afford imidazo[1,2-a]pyridines in excellent yields. ®T3P acts as an activator for both DMSO in oxidation reaction and the Schiff base in nucleophilic addition reaction with isocyanides.
Keywords
®T3P , alcohols , 2-a]pyridines , Heterocycles , Three component reactions
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883266
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