Author/Authors :
Pathirana، نويسنده , , Charles and Huang، نويسنده , , Yande and Bolgar، نويسنده , , E. Mark and Li، نويسنده , , Danping and Suda، نويسنده , , Russell and Desai، نويسنده , , Divyakant and Yang، نويسنده , , Run-Ming and Prasad، نويسنده , , Siva J. and Palaniswamy، نويسنده , , Venkatapuram، نويسنده ,
Abstract :
Two degradants observed in a drug formulation of the hepatitis B drug entecavir (Baraclude®), 1 were shown to be identical to the products resulting from the condensation between glyceraldehyde and the guanine nucleoside. The reaction products, 2a and 2b were identified by the analysis of comprehensive NMR data to be two diastereomeric derivatives of alanine implying a novel rearrangement in the reaction between glyceraldehyde and 1.
Keywords :
guanine , Alanine , Condensation , glyceraldehyde , Degradants
