Title of article
Identification of amino acid derivatives as condensation products between glyceraldehyde and guanine nucleoside
Author/Authors
Pathirana، نويسنده , , Charles and Huang، نويسنده , , Yande and Bolgar، نويسنده , , E. Mark and Li، نويسنده , , Danping and Suda، نويسنده , , Russell and Desai، نويسنده , , Divyakant and Yang، نويسنده , , Run-Ming and Prasad، نويسنده , , Siva J. and Palaniswamy، نويسنده , , Venkatapuram، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
2
From page
132
To page
133
Abstract
Two degradants observed in a drug formulation of the hepatitis B drug entecavir (Baraclude®), 1 were shown to be identical to the products resulting from the condensation between glyceraldehyde and the guanine nucleoside. The reaction products, 2a and 2b were identified by the analysis of comprehensive NMR data to be two diastereomeric derivatives of alanine implying a novel rearrangement in the reaction between glyceraldehyde and 1.
Keywords
guanine , Alanine , Condensation , glyceraldehyde , Degradants
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883291
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