Title of article :
A convenient one-pot synthesis of (R)-2-amino-3,3,3-trifluoro-2-methyl-N-phenylpropanamide derivatives
Author/Authors :
Li، نويسنده , , Tian-Wen and Shang، نويسنده , , Pei-Hua and Cheng، نويسنده , , Chang-Mei and Zhao، نويسنده , , Yu-Fen، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A convenient one-pot synthesis of enantiopure (R)-2-amino-3,3,3-trifluoro-2-methyl-N-phenylpropanamide derivatives has been developed. The key step in this synthetic methodology turned out to be the amide formation in which (R)-2-amino-3,3,3-trifluoro-2-methylpropanoic acid hydrochloride was simultaneously protected and activated by Vilsmeier reagent.
Keywords :
?-Trifluoromethyl-?-amino acids , Amide formation , One-pot , Vilsmeier reagent
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
