Title of article :
Diastereoselective nitrocyclopropanation of 2,5-dihydrothiophene-3-carbaldehydes
Author/Authors :
De Risi، نويسنده , , Carmela and Benetti، نويسنده , , Simonetta and Fogagnolo، نويسنده , , Marco and Bertolasi، نويسنده , , Valerio، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
An unprecedented domino Michael/α-alkylation reaction between 2,5-dihydrothiophene-3-carbaldehydes and bromonitromethane is presented. This process, efficiently catalyzed by DL-proline in the presence of MeOH/NaOAc system, provides access to novel 6-nitro-3-thiabicyclo[3.1.0]hexane-1-carbaldehyde derivatives in good yields with good to excellent diastereoselectivities.
Keywords :
S-Heterocycles , domino reactions , diastereoselectivity , Cyclopropanes
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
