The first total synthesis of acremomannolipin A, the potential Ca2+ signal modulator with a characteristic glycolipid structure, isolated from the filamentous fungus Acremonium strictum

The first total synthesis of acremomannolipin A, the potential Ca2+ signal modulator isolated from Acremonium strictum, was achieved by employing the characteristic stereoselective β-mannosylation of 4,6-O-benzylidene-protected mannosyl sulfoxide with a d-mannitol derivative in the presence of trifluoromethanesulfonic anhydride as the key reaction.