Author/Authors :
Zajdel، نويسنده , , Pawe? and Masurier، نويسنده , , Nicolas and Canale، نويسنده , , Vittorio and Verdie، نويسنده , , Pascal and Amblard، نويسنده , , Muriel and Paw?owski، نويسنده , , Maciej and Martinez، نويسنده , , Jean and Subra، نويسنده , , Gilles، نويسنده ,
Abstract :
Herein, we demonstrate the versatility of the pipecolic linker for the structural diversification of secondary amines with potential CNS activity. The solid-phase methods elaborated involved N1-indole sulfonylation, nitroindole and nitroarene reduction, and microwave-assisted Buchwald–Hartwig N-arylation.
Keywords :
Indole sulfonamide , N-Arylation , Nitro reduction , solid-phase synthesis , Pipecolic linker
