Title of article
Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist
Author/Authors
Chen، نويسنده , , Haijun and Ding، نويسنده , , Chunyong and Wild، نويسنده , , Christopher F. Liu، نويسنده , , Huiling and Wang، نويسنده , , Tianzhi and White، نويسنده , , Mark A. and Cheng، نويسنده , , Xiaodong and Zhou، نويسنده , , Jia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
1546
To page
1549
Abstract
A concise and efficient synthetic approach to producing a novel non-cyclic nucleotide EPAC antagonist ESI-09 and its new analogs is reported. Key features of the synthesis include a mild and reliable one-pot procedure for an isoxazole synthon, as well as a modified one-pot protocol for the cyanomethyl ketone key intermediate. The synthesis requires inexpensive starting materials and only three linear steps for the completion in a total yield of 53%.
Keywords
EPAC antagonist , Cyanomethyl ketone , Isoxazole , Modified Kowalski’s protocol , ESI-09
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884006
Link To Document