Title of article :
Synthesis of 2,6-diaryl-3-(trifluoromethyl)pyridines by regioselective Suzuki–Miyaura reactions of 2,6-dichloro-3-(trifluoromethyl)pyridine
Author/Authors :
Ahmed، نويسنده , , Shahzad and Sharif، نويسنده , , Muhammad and Shoaib، نويسنده , , Khurram and Reimann، نويسنده , , Sebastian and Iqbal، نويسنده , , Jamshed and Patonay، نويسنده , , Tamلs and Spannenberg، نويسنده , , Anke and Langer، نويسنده , , Peter، نويسنده ,
Abstract :
The Suzuki–Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphane ligands.
Keywords :
Organofluorine compounds , Catalysis , Suzuki–Miyaura reaction , regioselectivity , PALLADIUM
