Talaromins A and B, new cyclic peptides from the endophytic fungus Talaromyces wortmannii

Chemical investigation of the endophytic fungus Talaromyces wortmannii, isolated from Aloe vera, yielded two new cyclic peptides, talaromins A and B. Their structures were established on the basis of extensive NMR spectroscopic and mass spectrometric analysis. Both cyclopeptides contain ring systems comprised of six α-amino acid residues connected to a β-amino acid. The absolute configurations of the α-amino acids were determined by Marfey’s method.