Title of article :
Short stereoselective synthesis of (+)-crispine A via an N-sulfinyl Pictet–Spengler reaction
Author/Authors :
Sلnchez-Obregَn، نويسنده , , Rubén and Ortiz، نويسنده , , Benjamيn and Mastranzo، نويسنده , , Virginia M. and Yuste، نويسنده , , Francisco and Ruano، نويسنده , , José Luis Garcيa and Blanco-Favela، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
We report the highly stereoselective synthesis of (R)-(+)-crispine A from the (R)-N-sulfinyl amine 1 by using a one-pot process involving the Pictet–Spengler reaction with 4-chlorobutanal, removal of the sulfinyl group by protonolysis of the N–S bond and in situ cyclization, with a 55% overall yield.
Keywords :
Pictet–Spengler reaction , N-Sulfinyl amines , N-desulfinylation , Remote stereocontrol , (R)-(+)-Crispine A
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
