Author/Authors :
Li، نويسنده , , Jie Jack and Meng، نويسنده , , Wei and Wu، نويسنده , , Shung and Wu، نويسنده , , Yong-Jin and Guernon، نويسنده , , Jason and Allen، نويسنده , , Martin P. and Miller، نويسنده , , Michael M. and Cheng، نويسنده , , Peter T. and Chen، نويسنده , , Bang-chi، نويسنده ,
Abstract :
Previously unknown 2,5-bis-sulfonylpyrazines are prepared and their SNAr reactions are investigated. When 2 equiv of thiols are employed, the corresponding bis-thiopyrazines are obtained exclusively. However, phenols or alkoxides gave rise to only the corresponding mono-substituted aryloxy- or alkoxy-sulfonylpyrazines in excellent yields. A carbon nucleophile prepared by treating malonate with NaH also produced the corresponding mono-sulfonylpyrazines. Aliphatic amines and anilines only provided the mono-anilino-sulfonylpyrazines in poor to moderate yields.
