Title of article
Total synthesis of (−)-dihydroprotolichesterenic acid via diastereoselective conjugate addition to a chiral fumarate
Author/Authors
Hethcox، نويسنده , , J. Caleb and Shanahan، نويسنده , , Charles S. and Martin، نويسنده , , Stephen F.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
2074
To page
2076
Abstract
A diastereoselective conjugate addition of a variety of monoorganocuprates, Li[RCuI], to chiral fumarates to provide funtionalized succinates has been developed. The utility of this reaction is demonstrated in a concise total synthesis of (−)-dihydroprotolichesterenic acid that required only four steps and proceeded in an overall 31% yield.
Keywords
Succinate , conjugate addition , total synthesis , chiral auxiliary , butyrolactone
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884225
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