Title of article
Efficient and scalable synthesis of ketones via nucleophilic Grignard addition to nitriles using continuous flow chemistry
Author/Authors
Mateos، نويسنده , , Carlos and Rincَn، نويسنده , , Juan A. and Villanueva، نويسنده , , José، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
2226
To page
2230
Abstract
In the present Letter we report the development of efficient continuous flow chemistry conditions for the scalable preparation of ketones. This transformation is achieved via nucleophilic addition of Grignard reagents to the corresponding nitriles and imine hydrolysis by means of in-series plug flow reactors.
Keywords
Grignard reagents , Flow chemistry , Continuous process , ketones
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884291
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