Title of article :
Novel pathway for the synthesis of arylpropionamide-derived selective androgen receptor modulator (SARM) metabolites of andarine and ostarine
Author/Authors :
L. C. Schragl-Iro، نويسنده , , Katharina M. and Forsdahl، نويسنده , , Guro and Gmeiner، نويسنده , , Guenter and Enev، نويسنده , , Valentin S. and Gaertner، نويسنده , , Peter، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
O-Dephenylandarine and O-dephenylostarine, two SARM metabolites relevant for doping control analysis, were synthesized in their endogenous (S)-forms as well as in terms of their racemates. The enantiopure (S)-metabolites were obtained after six steps in 20% and 23% overall yield, the slightly modified racemic route provided the compounds in 28% and 31% total yield, respectively.
Keywords :
Arylpropionamides , Amide bond formation , Selective androgen receptor modulators , Andarine/ostarine metabolites
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
