Comparison of Cocaine-Induced Vasoconstriction of Left and Right Coronary Arterial Systems

In patients undergoing cardiac catheterization, we measured left and right coronary arterial dimensions before and 15 minutes after intranasal saline (n = 8) or cocaine (n = 8). In response to cocaine, left and right coronary arterial areas declined by 11 ± 6% and 12 ± 11%, respectively; thus, intranasal cocaine induces a similar magnitude of vasoconstriction of the left and right coronary arteries.