Title of article
Weinreb amide as an efficient reagent in the one pot synthesis of benzimidazoles and benzothiazoles
Author/Authors
Bommegowda، نويسنده , , Yadaganahalli K. and Lingaraju، نويسنده , , Gejjalagere S. and Thamas، نويسنده , , Saji and Vinay Kumar، نويسنده , , Koravangala S. and Pradeepa Kumara، نويسنده , , Challanayakanahally S. and Rangappa، نويسنده , , Kanchugarakoppal S. and Sadashiva، نويسنده , , Marilinganadoddi P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
2693
To page
2695
Abstract
One pot synthesis of 2-substituted benzimidazoles/benzothiazoles through condensation is followed by cyclization of Weinreb amide with o-diaminoarene or o-aminothiophenol is reported. In the presence of boron trifluoride etherate in 1,4-dioxane solvent, a high yield (75–94%) was achieved within 60 min. Weinreb amide shows high selectivity in the reaction, even in presence of other active functional groups such as carboxyl, halogen, cyano, and methoxy.
Keywords
Weinreb amide , Benzimidazoles , Boron trifluoride etherate , Benzothiazoles , o-Diaminoarene , o-Aminothiophenol
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884489
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