Title of article :
Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis
Author/Authors :
Wang، نويسنده , , Hongling and Cao، نويسنده , , Tuan-Wu and Jiang، نويسنده , , Fu-Qiang and Geng، نويسنده , , Chang-An and Zhang، نويسنده , , Xuemei and Huang، نويسنده , , Xiaoyan and Wang، نويسنده , , Li-Jun and Kang-He and Hao-Chen and Liang، نويسنده , , Wen-Juan and Rong، نويسنده , , Guang-Qing and Chen، نويسنده , , Ji-Jun، نويسنده ,
Abstract :
Swerpunilactones A (1) and B (2), two novel xanthone and secoiridoid heterodimers, together with their presumed biosynthetic precursors (±)-gentiolactone (3), bellidifolin (4), and norbellidifolin (5), were isolated from the whole plants of Swertia species. A plausible biogenetic pathway for swerpunilactones A and B was proposed. In vitro anti-hepatitis B virus assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited activities against the secretion of HBsAg (IC50 = 0.25 and 0.29 mM), HBeAg (IC50 = 0.86 and 0.31 mM), and HBV DNA replication (IC50 = 0.18 and 0.19 mM).
Keywords :
Swerpunilactones A–B , Anti-HBV activity , Swertia punicea , Swertia hispidicalyx , Swertia yunnanensis
