Copper-Catalyzed Aerobic Oxidative Amination of Arylboronic Acid with Aminal under Base-Free Conditions

A new process involving copper-catalyzed oxidative amination reaction of various arylboronic acids with aminals under mild conditions has been developed. The key copper-amide species involved in the C–N bond-forming process was generated via C–N bond cleavage of aminal under base-free conditions. Moderate yields of desired amination products can be obtained under mild conditions when air was served as oxidant and PhCO2H was used as an additive.