Title of article
First total synthesis of aerucyclamide B
Author/Authors
Peٌa، نويسنده , , Stella and Scarone، نويسنده , , Laura and Manta، نويسنده , , Eduardo and Serra، نويسنده , , Gloria، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
2806
To page
2808
Abstract
The first total synthesis of the antimalarial aerucyclamide B has been achieved in 9% overall yield. Two thiazoles and a dipeptide were used to prepare two open precursors of cyclo-Gly-l-allo-Thr-l-Ile-Thz-d-allo-Ile-Thz. Cyclodehydration with Deoxo-Fluor of the β-hydroxyamide present in the macrocycle, rendered aerucyclamide B (67%) and an unexpected fluorous derivative (28%).
Keywords
Oxa(thia)zole , Aerucyclamide , Macrocyclization , Hexacyclopeptide
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884540
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