Title of article
Facile domino reactions for the stereoselective assembly of highly functionalized bis-(trans-2,3-dihydrofuranyl) sulfides
Author/Authors
Beer Mohamed Vinosha، نويسنده , , Beer Mohamed and Perumal، نويسنده , , Subbu and Renuga، نويسنده , , Subbiah and Almansour، نويسنده , , Abdulrahman I.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
2837
To page
2840
Abstract
A facile stereoselective synthesis of a series of nineteen novel bis-(trans-2,3-dihydrofuranyl) sulfides from the reaction of (Z,Z)-2,2′-thiobis(1,3-diarylprop-2-en-1-ones) with substituted phenacyl bromides and pyridine in the presence of K2CO3 in acetonitrile via domino reactions is described. This transformation presumably occurs via pyridinium salt formation/ylide generation/Michael addition/intramolecular annulation domino sequence, involving the formation of two C–C and two C–O bonds and four stereocentres in a single step with complete stereoselectivity affording only one diastereomer.
Keywords
Z)-2 , 2?-Thiobis(1 , Michael addition , pyridinium ylide , stereoselectivity , Bis-(trans-2 , 3-dihydrofuranyl) sulfides , (Z , 3-diarylprop-2-en-1-ones)
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884554
Link To Document