Asymmetric total synthesis of Lycopodium alkaloid (+)-lycopladine A

Asymmetric total synthesis of (+)-lycopladine A (1) has been achieved. Key elements of the synthesis include an efficient Helquist annulation to assemble the cis-fused 6/5 bicycle, Stille coupling reaction to elongate the allylic side chain, and Krِhnke pyridine synthesis to set the pyridine core at the final stage.