Title of article
Design, synthesis, and biological activities of triazole tubulysin V analogue
Author/Authors
Yang، نويسنده , , Xiudong and Dong، نويسنده , , Changming and Chen، نويسنده , , Jian and Liu، نويسنده , , Yun-qi and HAN، نويسنده , , Bin and Zhang، نويسنده , , Quan and Chen، نويسنده , , Yue، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
2986
To page
2988
Abstract
A tubulysin V analogue with triazole/Me modified Tuv fragment was synthesized in 14 linear steps. The triazoltubulysin analogue maintains significant biological activities against several cancer cell lines, and then provides a new insight into the biological conformation of tubulysins.
Keywords
Synthesis , Triazole , biological activity , Click reaction , Tubulysin
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884612
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