Synthesis of biologically important phthalazinones, 2,3-benzoxazin-1-ones and isoindolinones from ninhydrin and their antimicrobial activity

Biologically important phthalazinones, 2,3-benzoxazin-1-ones and isoindolinones have been synthesized from easily available ninhydrin in good yields. The appropriate ninhydrin adducts 2,2,-diaryl-1,3-indanediones and 3-(diarylmethylene)isobenzofuranones were treated with various nucleophiles like hydrazine hydrate, hydroxylamine, and phenylhydrazin to accomplish the heterocycles. The synthesized compounds were assayed for their antibacterial activity and showed significant activity against both the selected Gram positive and Gram negative bacteria, suggesting possible scope of using as antimicrobials.