Author/Authors :
Mikula، نويسنده , , Hannes and Sohr، نويسنده , , Barbara and Skrinjar، نويسنده , , Philipp and Weber، نويسنده , , Julia and Hametner، نويسنده , , Christian and Berthiller، نويسنده , , Franz and Krska، نويسنده , , Rudolf and Adam، نويسنده , , Gerhard and Frِhlich، نويسنده , , Johannes، نويسنده ,
Abstract :
The chemical sulfation of β-resorcylic acid esters was investigated by applying state of the art procedures for the synthesis and deprotection of 2,2,2-trichloroethyl protected sulfates as appropriate intermediates. The selectivity of monosulfation was studied and reaction optimization was performed considering the effect of the solvent, different bases as well as the sulfation reagent itself. Finally the obtained protocols were applied for the first synthesis of zearalenone-14-sulfate (ammonium salt), an important conjugated (masked) mycotoxin, as reference material for further investigations in the field of bioanalytics as well as toxicology.
Keywords :
Resorcylic acid lactone , Phase II metabolite , Zearalenone , sulfate , Masked mycotoxin
