Title of article
Efficient synthesis of cytotoxic pyrido[1,2-e]purines from purines employing direct C-allylation and RCM–oxidation as key steps
Author/Authors
Marzouk، نويسنده , , Victor H.R. and Hennum، نويسنده , , Martin A. Gundersen، نويسنده , , Lise-Lotte، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
3437
To page
3439
Abstract
Cytotoxic pyrido[1,2-e]purines are readily available from 8,9-diallylpurines by ring-closing metathesis (RCM) followed by oxidation. The 8,9-diallylpurines were synthesized conveniently by addition of allylmagnesium bromide to the corresponding C-8 unsubstituted purines, followed by rearomatization of the adducts.
Keywords
Oxidation , pyridopurines , ring-closing metathesis , cytotoxic compounds , allylation
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884798
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