Author/Authors :
Guo، نويسنده , , Qi-Xiang and Zhang، نويسنده , , Lijun and Song، نويسنده , , Liu and Xu، نويسنده , , Biao and Xiao، نويسنده , , Dong-Rong and Peng، نويسنده , , Yun-Gui، نويسنده ,
Abstract :
An efficient DMAP catalyzed tandem aldol/imidization reaction of α-isothiocyanato esters with α-ketoamides is described, affording ring-fused thiocarbamates bearing contiguous quaternary carbon centers with up to 99% yield in a completely diastereoselective fashion. This method has a wide range of substrate scope and can be used in the synthesis of pyrrolidines.
Keywords :
Tandem reaction , aldol reaction , Imidization reaction , DMAP , thiocarbamate
