Title of article :
Enantioselective Grignard addition to nitroolefin
Author/Authors :
Reddy، نويسنده , , Prashanth and Bandichhor، نويسنده , , Rakeshwar، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A novel synthesis of naproxen utilizing nitroaldol, 1,4-addition and Nef reaction is demonstrated where the desired S-enantiomer is achieved by resolution. Further to this first enantioselective 1,4-addition of Grignard reagent to nitroolefin is demonstrated to synthesize derivatives of naproxen.
Keywords :
nitroaldol , 1 , Nef reaction , 4-addition , Naproxen , Anti-inflammatory drug
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
