Author/Authors :
Hong، نويسنده , , Seong Su and Choi، نويسنده , , Yun-Hyeok and Jeong، نويسنده , , Wonsik and Kwon، نويسنده , , Jin Gwan and Kim، نويسنده , , Jin Kyu and Seo، نويسنده , , Changon and Ahn، نويسنده , , Eun-kyung and Lee، نويسنده , , Hyun Hwa and Ko، نويسنده , , Han-Jik and Seo، نويسنده , , Dong Wan and Oh، نويسنده , , Joa Sub Oh، نويسنده ,
Abstract :
Two new furostanol glycosides, named terrestrinones A1/A2 (1a/1b), were isolated from the fruits of Tribulus terrestris L. together with four known compounds, and their structures were determined by spectroscopic methods, including 2D NMR experiments. All of the isolates (1–5) were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells. Of these, compounds 2 and 3 inhibited nitric oxide production with IC50 values of 7.1 and 46.6 μM.
Keywords :
Nitric oxide inhibitor , Terrestrinone A1 , Furostanol glycoside , Tribulus terrestris
