Title of article :
Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species
Author/Authors :
El-Elimat، نويسنده , , Tamam and Figueroa، نويسنده , , Mario and Raja، نويسنده , , Huzefa A. and Adcock، نويسنده , , Audrey F. and Kroll، نويسنده , , David J. and Swanson، نويسنده , , Steven M. and Wani، نويسنده , , Mansukh C. and Pearce، نويسنده , , Cedric J. and Oberlies، نويسنده , , Nicholas H.، نويسنده ,
Abstract :
An organic extract of a filamentous fungus (MSX 58801), identified as a Volutella sp. (Hypocreales, Ascomycota), displayed moderate cytotoxic activity against NCI-H460 human large cell lung carcinoma. Bioactivity-directed fractionation led to the isolation of three γ-lactones having the furo[3,4-b]pyran-5-one bicyclic ring system [waol A (1), trans-dihydrowaol A (2), and cis-dihydrowaol A (3)]. The structures were elucidated using a set of spectroscopic and spectrometric techniques; the absolute configuration of 2 was established via a modified Mosher’s ester method. Compounds 1 and 2 were evaluated for cytotoxicity against a human cancer cell panel.
Keywords :
filamentous fungi , ?-Lactone , Polyketide , Cytotoxicty , Waol A
