Author/Authors :
Liu، نويسنده , , Fei and Wu، نويسنده , , Xing-De and He، نويسنده , , Juan and Deng، نويسنده , , Xu and Peng، نويسنده , , Li-Yan and Luo، نويسنده , , Huai-Rong and Zhao، نويسنده , , Qin-Shi، نويسنده ,
Abstract :
A phytochemical study on Lycopodium casuarinoides has led to the isolation of two new C16N2-type Lycopodium alkaloids, casuarine A (1), a cage-like structure featured with a fused 6/6/6/6/6 pentacyclic ring system, and casuarine B (2). Their structures were elucidated based on the spectroscopic data and further confirmed by X-ray analysis. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that compound 2 exhibited moderate anti-AChE activity with IC50 46.40 μM.
Keywords :
Casuarines A and B , Anti-AChE activity , Lycopodium alkaloid , Lycopodium casuarinoides
