Author/Authors :
Guo، نويسنده , , Qi-Xiang and Wen، نويسنده , , Wei and Fu، نويسنده , , Li-Na and Zhang، نويسنده , , Shun-En and Zhang، نويسنده , , Lan-Xi and Liu، نويسنده , , Yu-Wan and Xu، نويسنده , , Biao and Xiong، نويسنده , , Yan، نويسنده ,
Abstract :
An efficient aldol reaction of indole-3-carbaldehydes with ketones is described. O-TBS-protected l-threonine promoted the aldol addition of ketones to indole-3-carbaldehydes affording 3-indolylmethanols with good to excellent yields and diastereoselectivities, and excellent enantioselectivities.
Keywords :
asymmetric synthesis , Indolylmethanol , organocatalysis , 3-Substituted indole , aldol reaction
