Title of article
A three-component reaction between 1-substituted-2-methylimidazoles, cyanophenylacetylene, and various aldehydes: stereoselective synthesis of (Z)-(2-cyano-1-phenyl)vinyl ethers of 2-(2-hydroxyalkyl)imidazoles
Author/Authors
Trofimov، نويسنده , , Boris A. and Andriyankova، نويسنده , , Ludmila V. and Nikitina، نويسنده , , Lina P. and Belyaeva، نويسنده , , Kseniya V. and Mal’kina، نويسنده , , Anastasiya G. and Afonin، نويسنده , , Andrei V. and Ushakov، نويسنده , , Igor’ A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
4693
To page
4696
Abstract
A three-component reaction between 1-substituted-2-methylimidazoles (1-Me, Bn), cyanophenylacetylene, and aliphatic (Me, i-Pr, n-Bu) and aromatic (Ph, 4-CN-, 4-O2N-C6H4) aldehydes occurs without a catalyst or solvent at room temperature (20–25 °С) to afford stereoselectively (Z)-(2-cyano-1-phenyl)vinyl ethers of 2-hydroxyalkylimidazoles in 26–57% yields.
Keywords
Acetylene , Zwitterionic intermediates , imidazoles , Aldehydes , multicomponent reactions
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885331
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