Author/Authors :
Verdan، نويسنده , , Maria Helena and Unemoto، نويسنده , , Lilian K. and Faria، نويسنده , , Ricardo T. and Salvador، نويسنده , , Marcos José and de Sل، نويسنده , , Eduardo Lemos and Barison، نويسنده , , Andersson and Stefanello، نويسنده , , Maria Elida A.، نويسنده ,
Abstract :
Chemical investigation of Sinningia leucotricha (Gesneriaceae) resulted in the isolation of leucotrichoic acid, a sesquiterpene with a novel triquinane skeleton, and the known triterpenes hederagenin and 23-hydroxyursolic acid. The chemical structures of all compounds were elucidated through spectroscopic analysis (NMR and MS). The conformational stability of the new compound was analyzed by density theory functional methods. A possible biogenesis for the new compound is proposed. Leucotrichoic acid was inactive against a panel of human cancer cell lines.
Keywords :
Sinningia , Gesneriaceae , Triquinane , NMR , sesquiterpene
