Enantio- and diastereoselective synthesis of β-substituted-δ-aminoboronic esters from nitriles

The first stereocontrolled synthesis of the title δ-aminoboronic esters—proceeding from commercially available nitriles—via a reduction, Brown’s ‘allyl’ boration reaction, a Boc-protection, a hydroboration, an oxidative elimination of α-pinene, and an esterification reaction, has been reported in excellent enantio- and diastereoselectivities.