Title of article
Unusual nor-sesquiterpene lactone from the fruits of Illicium henryi
Author/Authors
Liu، نويسنده , , Jifeng and Wang، نويسنده , , Yafeng and Bi، نويسنده , , Ya-Ping and Li، نويسنده , , Hui-Juan and Jia، نويسنده , , Lu and Bi، نويسنده , , Yuefeng and Zhang، نويسنده , , Yan-Bing، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
4834
To page
4836
Abstract
Henrylactone F (1), an unusual nor-sesquiterpene lactone, together with a pair of stereoisomers, henrylactone G (2) and anislactone B (3), was discovered from the fruits of Illicium henryi. Their structures were elucidated based on extensive spectroscopic data analyses as well as X-ray diffraction. The anti-hepatitis B virus (HBV) activity of the isolates against the HBV transfected Hep G2.2.15 cell line was evaluated. Anislactone B (3) possessed a high therapeutic index (TI = 43.4) on HBeAg secretion of the Hep G2.2.15 cell line with an IC50 value of 0.079 ± 0.035 mM.
Keywords
Sesquiterpene lactone , Nor-sesquiterpene lactone , Anti-HBV activity , Illicium henryi , Illiciaceae
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885378
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