Title of article :
Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditions
Author/Authors :
Ravinder، نويسنده , , B. and Rajeswar Reddy، نويسنده , , S. and Panasa Reddy، نويسنده , , A. and Bandichhor، نويسنده , , Rakeshwar، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
An expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed by reduction with LiAlH4. Various amides/lactams including hindered amides and secondary amides gave the corresponding amines in good to excellent yields. This novel protocol has a wide substrate scope and shows good functional group tolerance with high stereoretention.
Keywords :
reductive amination , trimethylsilyl chloride , Lithium aluminum hydride
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
