Title of article
Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditions
Author/Authors
Ravinder، نويسنده , , B. and Rajeswar Reddy، نويسنده , , S. and Panasa Reddy، نويسنده , , A. and Bandichhor، نويسنده , , Rakeshwar، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
4908
To page
4913
Abstract
An expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed by reduction with LiAlH4. Various amides/lactams including hindered amides and secondary amides gave the corresponding amines in good to excellent yields. This novel protocol has a wide substrate scope and shows good functional group tolerance with high stereoretention.
Keywords
reductive amination , trimethylsilyl chloride , Lithium aluminum hydride
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885414
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