Author/Authors :
Yajima، نويسنده , , Arata and Urao، نويسنده , , Shota and Yoshioka، نويسنده , , Yasukiyo and Abe، نويسنده , , Naoki and Katsuta، نويسنده , , Ryo and Nukada، نويسنده , , Tomoo، نويسنده ,
Abstract :
The first total syntheses of 5′-O-desmethylterphenyllin and three related p-terphenyls have been achieved. The methodology features a Suzuki–Miyaura coupling reaction with a hindered aryl chloride as the key step. Two of the four synthesized 5′-O-desmethylterphenyllins exhibit moderate TNF-α release-inhibitory activity toward RBL-2H3 cells.
Keywords :
p-Terphenyls , Suzuki–Miyaura coupling , TNF-? , Ubiquitin-specific peptidase
