Title of article
Biocatalyzed synthesis of both enantiopure fluoromisonidazole antipodes
Author/Authors
Borzecka-Prokop، B. نويسنده , , Wioleta and Lavandera، نويسنده , , Iv?n and Gotor، نويسنده , , Vicente، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
5022
To page
5025
Abstract
Fluoromisonidazole (FMISO or F-MISO) is a radiotracer for positron emission tomography when 18F-labeled and is administrated in its racemic form. Herein, a straightforward synthesis of both enantiopure antipodes is proposed through a one-pot two-step microwave protocol to obtain a fluorinated ketone precursor followed by bioreduction using alcohol dehydrogenases from Rhodococcus ruber (ADH-A) or Lactobacillus brevis (LBADH).
Keywords
Fluorohydrins , Biocatalysis , alcohol dehydrogenases , Fluoromisonidazole , Microwave-assisted synthesis
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885467
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