Title of article
New chalcone dimers from Caesalpinia ferrea Mart act as potent inhibitors of DNA topoisomerase II
Author/Authors
Ohira، نويسنده , , Susumu and Takaya، نويسنده , , Kyouhei and Mitsui، نويسنده , , Taichi and Kido، نويسنده , , Masahiro and Kakumoto، نويسنده , , Kazuyuki and Hayashi، نويسنده , , Ken-ichiro and Kuboki، نويسنده , , Atsuhito and Tani، نويسنده , , Hiroyuki and Ikeda، نويسنده , , Shogo and Iinuma، نويسنده , , Munekazu and Akao، نويسنده , , Yukihiro and Nozaki، نويسنده , , Hiroshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
5052
To page
5055
Abstract
New chalcone dimers, pauferrol B (2), and pauferrol C (3), were isolated from the stems of Caesalpinia ferrea Mart, and their structures were determined on the basis of 2D NMR spectroscopy. These new chalcone dimers showed potent inhibitory activities against human topoisomerase II and cell proliferation via the induction of apoptosis in human leukemia HL 60 cells. Absolute configurations of 2 and 3 were estimated by the comparison of CD spectra with a dihydrobenzofuran derivative 4, which was enantioselectively synthesized from 2-hydroxyphenyl acetic acid.
Keywords
absolute configuration , trans-Substituted dihydrobenzofuran , Topo II inhibitor , Chalcone dimer , Caesalpinia ferrea Mart
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885479
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