Author/Authors :
Ohira، نويسنده , , Susumu and Takaya، نويسنده , , Kyouhei and Mitsui، نويسنده , , Taichi and Kido، نويسنده , , Masahiro and Kakumoto، نويسنده , , Kazuyuki and Hayashi، نويسنده , , Ken-ichiro and Kuboki، نويسنده , , Atsuhito and Tani، نويسنده , , Hiroyuki and Ikeda، نويسنده , , Shogo and Iinuma، نويسنده , , Munekazu and Akao، نويسنده , , Yukihiro and Nozaki، نويسنده , , Hiroshi، نويسنده ,
Abstract :
New chalcone dimers, pauferrol B (2), and pauferrol C (3), were isolated from the stems of Caesalpinia ferrea Mart, and their structures were determined on the basis of 2D NMR spectroscopy. These new chalcone dimers showed potent inhibitory activities against human topoisomerase II and cell proliferation via the induction of apoptosis in human leukemia HL 60 cells. Absolute configurations of 2 and 3 were estimated by the comparison of CD spectra with a dihydrobenzofuran derivative 4, which was enantioselectively synthesized from 2-hydroxyphenyl acetic acid.
Keywords :
absolute configuration , trans-Substituted dihydrobenzofuran , Topo II inhibitor , Chalcone dimer , Caesalpinia ferrea Mart
