Title of article
Reductive iodonio-Claisen rearrangement of iodothiophene diacetates with allylsilanes: formal synthesis of Plavix®
Author/Authors
Nguyen، نويسنده , , Hai and Khatri، نويسنده , , Hem Raj and Zhu، نويسنده , , Jianglong، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
5464
To page
5466
Abstract
Iodothiophene diacetates react with allyltrimethylsilanes in the presence of boron trifluoride diethyl etherate to afford corresponding ortho-allyliodothiophenes via reductive iodonio-Claisen rearrangement. This method has been successfully applied to the synthesis of Plavix®, a blood clot inhibitor used to reduce the risk of heart attack and stroke.
Keywords
hypervalent iodine , Claisen rearrangement , pericyclic reaction , allylation , Heterocycles
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885622
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